TNYA thesis
Tenaya Therapeutics, a research-oriented biopharmaceutical company, is dedicated to developing and producing novel therapeutic drugs for the treatment of heart disease. Tenaya’s approach focuses on addressing the underlying causes of heart disease, including rare genetic disorders. The company’s strategy encompasses gene therapies, cellular regeneration, and precision medicines.
Heart disease stands as the world’s leading cause of death among adults, making its treatment a crucial area of focus. Tenaya currently has two primary drug candidates under investigation, TN-201 and TN-401, for the treatment of MYBPC3-associated hypertrophic cardiomyopathy and PKP2-associated arrhythmogenic right ventricular cardiomyopathy, respectively.
The leading candidate, TN-201, is currently undergoing a Phase 1b human clinical trial. The study aims to assess the safety and tolerability of TN-201 in up to 24 adults. Data from the first patient cohort in the study is anticipated to be released in December, which could be a significant milestone for the stock. Meanwhile, enrollment is ongoing for the second cohort.
The second candidate, TN-401, commenced its Phase 1 RIDGE-1 trial earlier this year. This global, open-label, dose-escalation study, which will continue patient dosing until Q4 2024, seeks to evaluate the safety, tolerability, and effectiveness of a single intravenous dose of TN-401.
Morgan Stanley analyst Michael Ulz views Tenaya as a compelling investment opportunity, with TN-201 serving as the primary value driver. Ulz highlights that interim Phase 1b MyPEAK-1 data for TN-201 in nHCM is expected in December and could represent a pivotal catalyst for Tenaya’s lead program. Ulz notes that the initial data suggests a favorable risk-reward profile, potentially leading to early de-risking, followed by more robust data in 2025.
The consensus view indicates that Morgan Stanley’s bullish perspective is not exceptional. TNYA stock has a unanimous Strong Buy consensus rating, based on seven recent positive analyst reviews. The stock’s current trading price of $1.94 and its average target price of $20.20 collectively suggest an impressive upside potential of 941% over the next 12 months.
TLDR;
Could be another great biotech company to buy into now slowly moving into 2025.